In Little Nightmares: Secrets of the Maw, Six's role is minor, seen locked up in a cage alongside the Runaway Kid and being seen crossing the shoe room. In the second issue, she brought them a music box with a mirror in it which caused one of the children to panic and explain their encounter with the Mirror Monster.
The first was about the boy who evaded the North Wind. While with them, they exchanged stories with her about their past experiences. The difference is that in the comic series, she discovered a group of other children and decided to survive with them. In the series, she is seen evading the same main enemies as she did in the first game. Before this, she was wondering the streets of the town that the Guests inhabited.
In the series, it was revealed that she was brought to the Maw by a mysterious figure known as the Ferryman in a boat. Six made two appearances in the Little Nightmares comic series. Six's stomach growls, hinting to the events of the first game. In the game's secret ending, Six encounters a mysterious shadow/hologram version of herself, which leads her to a poster of the Maw.
In a sudden turn of events, Six lets go of Mono, allowing him to fall into the depths of the tower, an act which eventually leads to Mono becoming the Thin Man himself. Pursued by the tower's core, a mass of flesh and eyes, the children attempt to jump across a chasm - however, only Six is able to make the jump and Mono is left hanging on to her hand. Mono destroys it and returns Six back to normal, but the tower begins to collapse and the two are forced to flee. Six is later encountered within the Signal Tower, now having been transformed into a massive beast controlled by a music box. The Thin Man suddenly appears and captures Six, forcing Mono to navigate the city and eventually destroy the Thin Man. Traveling even further into the city, they encounter the Viewers, who have been twisted by television signals emitted by the Signal Tower, run by a being called the Thin Man. They then enter a hospital, encountering the mannequin-like Patients and their creator, the obese Doctor who is later killed by the two children when they trap him in an incinerator. The two narrowly escape the Teacher and journey further into the city on the way, Six dons her iconic yellow raincoat for the first time. Six is temporarily taken hostage by the Bullies, but is freed by Mono. They then enter a school, filled with psychotic porcelain Bullies and run by the cruel, long-necked Teacher. The two children then use a door as a raft, sailing across a large body of water and entering the Pale City. While originally hesitant to stick with Mono, Six quickly decides to cooperate with him and the two escape, fleeing the Wilderness in which the Hunter resides and eventually killing him with another rifle. Six is discovered by Mono, Little Nightmares 2's protagonist, in a cage in a cabin owned by a rifle-wielding monster known only as the Hunter. Both the Pretender and the Girl in the Yellow Raincoat fall into the water, and Six is last seen walking down the ledges toward the water. Doing so prompted Six to aid the little girl by dropping a bolder on the Pretender, but it only temporarily knocked her out and broke the ledge that they were standing on. In Very Little Nightmares, she appears at the end of the game where the Girl in the Yellow Raincoat helped her to escape the Pretender.